Clascoterone is a clinical synthetic ingredient that can inhibit androgens like dihydrotestosterone (DHT) and testosterone—which oftentimes are the main culprits of hormonal acne. In case you need a briefer: Testosterone can increase oil production in the skin and cause skin cells to become more “sticky,” making it more difficult for the cells to shed, thus clogging the pores.
This new ingredient, it seems, can keep those hormones from going haywire—and thus, less acne along your jawline. And in addition to demonstrating those great results, the side effects are also minimal. The only frequent reaction when using the cream twice a day, according to one study, was some redness and scaling (which is actually quite common in many prescription topicals).
But what’s most exciting about this new ingredient is the fact that it doesn’t require any sort of oral medication. While there certainly are acne-fighting ingredients to try at home (retinoids, salicylic acid, benzoyl peroxide, et al), topicals that approach the androgens themselves are limited. As a result, oral antibiotics that can effectively target those hormones have routinely been the go-to’s for this type of acne—especially in severe cases. All this to say, a topical cream with that same clinical strength is certainly cutting-edge.
Take it from board-certified dermatologist Michael Gold, M.D., investigator and medical director of the Gold Skin Care Center and the Tennessee Clinical Research Center: “This game-changing topical drug offers a non-antibiotic approach to people with acne, by targeting the androgen receptors directly in the skin. It fills a longstanding gap in acne therapy.” he says in a press release. “After 40 years, it provides a much-anticipated, complementary new approach to treat acne.”